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. 2020 Jan 10;48(3):1572–1582. doi: 10.1093/nar/gkz1216

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© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 4. — A model of tRNA docking onto hBCDIN3D. (A) Docking of tRNA^His onto hBCDIN3D. Superimposition of hBCDIN3D (purple) on the structure of the MTD of hMePCE (cyan) complexed with 7SK SL1p (blue). tRNA^His (gray) was modeled such that the acceptor helix of tRNA^His superimposed well onto the 5′-end and 3′-single-stranded region of SL1p. See ‘Materials and Methods’ section for details. (B) α6′ would interact with the major groove of the acceptor helix of tRNA^His, and α0 would wedge the G₋₁:A₇₃ mispair of tRNA^His. (C) A detailed stereo view of the interaction between the acceptor helix of tRNA^His and BCDIN3D in (B). tRNA is shown as a gray stick model.