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Mechanism of the different activities between MePCE and BCDIN3D. (A) 5′-γ-Phosphate methylation of 7SK RNA by MePCE. (B) 5′-α-Phosphate methylation of G−1 of tRNAHis by BCDIN3D. α0 wedges the G−1:A73 mispair and the 5′-α-phosphate reaches the catalytic site for methylation. (C) tRNAHis with G−1:C73 is not methylated, since α0 would not wedge the base pair, and the 5′-α-phosphate cannot reach the active site for methylation.
