Table 5.

Comparison of the APOBEC3 protein deamination preferences with TC or CT targets in oligonucleotides with different predicted DNA secondary structures^a

Protein\preference	Open versus ‘−1’ T open & target C stem versus stem (TC target)	Open versus ‘+1’ T stem & target C open versus stem (CT target)
A3A	open ≧ ‘−1’ T open & target C stem ≧ stem	stem > open = ‘+1’ T stem & target C open
A3F	open = stem = ‘−1’ T open & target C stem	open = stem = ‘+1’ T stem & target C open
A3G	open = stem ≧ ‘−1’ T open & target C stem	stem > open = ‘+1’ T stem & target C open
A3H	open ≧ ‘−1’ T open & target C stem > stem	‘+1’ T stem & target C open ≧ open > stem

^aThe predicted target cytidine for deamination is indicated by an underline in each oligonucleotide. ‘>’ = greater than; ‘<’ = smaller than; ‘ = ’ = equal; ‘≧’ = greater or equal; ‘≦’ = smaller or equal. Statistical differences between groups were analyzed by using a one-way ANOVA test, with significance having a P-value of P < 0.05.