Figure 4.

Observed ND7 5′ editing pathways in the TREU 667 cell line (A) and the EATRO 164 cell line grown in SDM79 (B) and SDM80 (C). U = unedited transcripts. For arrow, gRNA and mRNA naming descriptors see Figure 1. + indicates that more than one mRNA form was condensed into this circle to simplify the figure (See Supplementary Figure S4). Condensed forms encode largely the same amino acid sequence with only small variants. Terminal dots are colored blue for reading frame 1, magenta for reading frame 2, or green for reading frame 3. Boxed green dots have no in frame AUG start codon but are translatable into reading frame 3 with the use of an alternative start codon (UUG).