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Observed CR3 editing pathways in the TREU 667 cell line. U = unedited transcripts. For arrow and gRNA naming descriptors see Figure 1. gRNAs with prime designations indicate extensively overlapped gRNAs both needed to cover a single editing block. Terminal dots are colored blue for reading frame 1 or magenta for reading frame 2. Boxed magenta dots have no functional start codon but are translatable into reading frame 2 with the use of an alternative start codon (UUG).
