Table 5.
Exposures associated with the presence of fibrosis in analysed participants (n=3600)
| Participants with fibrosis | Unadjusted OR (95% CI) | p value | Adjusted for | Adjusted OR (95% CI) | p value | |
|---|---|---|---|---|---|---|
| Alcohol consumption* | ||||||
| Low risk | 37/1610 (2·3%) | Reference | .. | CAP, BMI, smoking, social class | Reference | .. |
| Hazardous | 39/1520 (2·6%) | 1·12 (0·71–1·77) | 0·63 | .. | 1·38 (0·79–2·41) | 0·26 |
| Harmful (alcohol use disorder) | 20/470 (4·3%) | 1·89 (1·09–3·29) | 0·02 | .. | 2·11 (1·02–4·37) | 0·04 |
| Steatosis | ||||||
| S0 | 69/2795 (2·5%) | Reference | .. | Excessive alcohol intake*, BMI, smoking, social class | Reference | .. |
| S1 | 6/264 (2·3%) | 0·92 (0·40–2·14) | 0·84 | .. | 0·60 (0·21–1·73) | 0·34 |
| S2 | 3/109 (2·8%) | 1·12 (0·35–3·61) | 0·85 | .. | 1·19 (0·35–4·01) | 0·78 |
| S3 | 16/343 (4·7%) | 1·93 (1·11–3·37) | 0·02 | .. | 0·83 (0·35–1·96) | 0·67 |
| Alcohol use disorder and steatosis | ||||||
| No alcohol use disorder or steatosis | 27/1231 (2·2%) | Reference | .. | Smoking, social class | Reference | 0·13 |
| Steatosis, no alcohol use disorder | 10/346 (2·9%) | 1·33 (0·64–2·77) | 0·45 | .. | 1·56 (0·63–3·84) | 0·33 |
| Alcohol use disorder, no steatosis | 13/368 (3·5%) | 1·63 (0·83–3·20) | 0·15 | .. | 2·05 (0·86–4·91) | 0·11 |
| Alcohol use disorder and steatosis | 7/94 (7·4%) | 3·59 (1·52–8·47) | 0·004 | .. | 4·02 (1·24–13·02) | 0·02 |
| Sex | ||||||
| Male | 54/1391 (3·9%) | Reference | .. | BMI, excessive alcohol intake*, smoking, social class | Reference | .. |
| Female | 42/2209 (1·9%) | 0·48 (0·32–0·72) | <0·0001 | .. | 0·51 (0·31–0·84) | 0·008 |
OR=odds ratio. CAP=controlled attenuation parameter.
*
According to AUDIT-C score and the Diagnostic and Statistical Manual of Mental Disorders-5 criteria for alcohol use disorder;23 excessive intake defined as hazardous or harmful consumption.