Table 1.
Descriptive summaries for outcome measures at baseline, 12 months, and 24 months
|
Telephone-CBT group |
Web-CBT group |
TAU group |
Overall |
|||||
|---|---|---|---|---|---|---|---|---|
| Number of patients | Mean (SD) or n (%) | Number of patients | Mean (SD) orn (%) | Number of patients | Mean (SD) or n (%) | Number of patients | Mean (SD) or n (%) | |
| IBS-SSS | ||||||||
| Baseline | 186 | 272·3 (95·5) | 185 | 264·2 (99·3) | 187 | 258·5 (91·6) | 558 | 265·0 (95·5) |
| 12 months | 136 | 139·0 (94·8) | 124 | 163·0 (108·8) | 131 | 205·6 (100·5) | 391 | 168·9 (104·8) |
| 24 months | 119 | 164·4 (94·9) | 99 | 167·6 (107·5) | 105 | 197·9 (98·6) | 323 | 176·3 (100·9) |
| Responders* (12 months) | 136 | 99 (73%) | 124 | 82 (66%) | 131 | 58 (44%) | 391 | 239 (61%) |
| Responders* (24 months) | 119 | 84 (71%) | 99 | 62 (63%) | 105 | 48 (46%) | 323 | 194 (60%) |
| WSAS | ||||||||
| Baseline | 186 | 12·3 (8·8) | 185 | 13·0 (9·3) | 187 | 12·4 (7·4) | 558 | 12·5 (8·5) |
| 12 months | 138 | 6·0 (7·5) | 124 | 7·4 (7·7) | 132 | 10·8 (9·3) | 394 | 8·1 (8·5) |
| 24 months | 118 | 6·1 (7·6) | 99 | 7·3 (8·0) | 105 | 9·7 (8·5) | 322 | 7·6 (8·1) |
| HADS | ||||||||
| Baseline | 186 | 16·1 (6·9) | 185 | 17·0 (7·3) | 187 | 16·0 (6·4) | 558 | 16·4 (6·9) |
| 12 months | 120 | 12·2 (6·5) | 117 | 12·7 (7·4) | 113 | 15·0 (7·2) | 350 | 13·3 (7·1) |
| 24 months | 118 | 12·1 (6·4) | 98 | 12·2 (7·6) | 103 | 15·1 (6·6) | 319 | 13·1 (7·0) |
| PEQ† | ||||||||
| Non-responders (12 months) | 138 | 30 (22%) | 124 | 56 (45%) | 132 | 101 (77%) | 394 | 187 (47%) |
| Responders (12 months) | 138 | 108 (78%) | 124 | 68 (55%) | 132 | 31 (23%) | 394 | 207 (53%) |
| Non-responders (24 months) | 119 | 25 (21%) | 99 | 38 (38%) | 103 | 75 (73%) | 321 | 138 (43%) |
| Responders (24 months) | 119 | 94 (79%) | 99 | 61 (62%) | 103 | 28 (27%) | 321 | 183 (57%) |
| SGA† | ||||||||
| Non-responders (12 months) | 138 | 21 (15%) | 124 | 31 (25%) | 132 | 77 (58%) | 394 | 129 (33%) |
| Responders (12 months) | 138 | 117 (85%) | 124 | 93 (75%) | 132 | 55 (42%) | 394 | 265 (67%) |
| Non-responders (24 months) | 45 | 5 (11%) | 35 | 17 (49%) | 44 | 22 (50%) | 124 | 44 (35%) |
| Responders (24 months)‡ | 45 | 40 (89%) | 35 | 18 (51%) | 44 | 22 (50%) | 124 | 80 (65%) |
CBT=cognitive behavioural therapy. TAU=treatment as usual. IBS–SSS=Irritable Bowel Syndrome Symptom Severity Score. WSAS=Work and Social Adjustment Scale. HADS=Hospital Anxiety and Depression Scale. PEQ=Patient Enablement Questionnaire. SGA=Subject's Global Assessment of Relief.
IBS-SSS responders were defined as participants who had a clinically significant change in IBS-SSS (≥50 points) from baseline to 24 months.
PEQ responders are defined as patients achieving a score of 6 or more; PEQ was not recorded at baseline.
SGA responders are defined as patients achieving a score of 1–3; SGA was not recorded at baseline and was only recorded at 24 months for participants who completed the outcome measures by paper questionnaire.