Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Feb 12;52:102658. doi: 10.1016/j.ebiom.2020.102658

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Fig 6 — Impact of MBOAT7 deletion on intracellular fat composition.

A)Heatmaps, which were generated calculating log2 fold change ratio between MBOAT7^−/−/wt absolute quantification. Red shading indicates the induction and blue shading indicates repression relative to the average levels of each lipid species across all samples. PI: phosphatidyl-inositol, PC: phosphatidyl-choline, PE: phosphatidyl-ethanolamine, DAG: diacylglycerol and TAG: triacylglycerols.

B)Hypothetical model of the impact of reduced MBOAT7 activity on intracellular phospholipid metabolism in hepatocytes. The consequences of MBOAT7 downregulation are shown by the red cross and arrows. When MBOAT7 is not functional, LysoPI (20:4) cannot be generated from LysoPI (16:0) or LysoPI (18:0), which therefore accumulate, together with their precursors PI (36:4) and PI (38:4). Accumulating saturated-PIs are then shunted to the synthesis of TAGs.

CDP: cytidine-diphosphate, CL: cardiolipin, DAG: diacylglycerol, TAG: triacylglycerols, G3P: glyceraldehyde-3-phosphate, LPA: lyso-phosphatidic acid, PA: phosphatidic acid, PC: phosphatidyl-choline, PE: phosphatidyl-ethanolamine, PG: phosphatidyl-glycerol, PI: phosphatidyl-inositol, PIP: phosphatidyl-inositol-phosphate, PS: phosphatidyl-serine (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.).