. 2019 Dec 26;6(2):173–179. doi: 10.1021/acsinfecdis.9b00396

Table 1. Initial Benzoxaborole–Benzimidazole Amide Leads^a.

ID	link atom	n	R	O. volvulus IC₅₀ (μM)^31,32	G2/M arrest IC₅₀ (μM)³³	MDCK-MDR1 P_app (A-B, ×10⁶ cm/s)³⁴⁻³⁶
1	NA	NA	NA	0.004	0.67	15.6
7a	6	0		4.55	>100	NT
7b	6	0	3,3-Me₂	>10	NT	NT
8a	6	1	3,3-Me₂	0.300	13	0.8
8b	3	1		0.426	10	NT
8c	6	1		0.421	>100	NT
8d	5	1	3,3-Me₂	0.042	2.54	0.5
9a	6	2	3,3-Me₂	0.004	0.555	0.7
12a	6	0	3,3-Me₂	>10	>100	NT

NT = not tested.

Table 1. Initial Benzoxaborole–Benzimidazole Amide Leadsa.