Table 2.
Effect of empagliflozin on morphometric parameters of different organs and body weight in the lean control and ZSF1 groups
| Control | Empa | ZSF1 | ZSF1 + Empa | |
|---|---|---|---|---|
| Spleen (mg mm−1) | 17.45 ± 0.38 | 16.55 ± 0.62 | 20.90 ± 0.32* | 18.53 ± 0.81# |
| Liver (mg mm−1) | 286.40 ± 12.58 | 264.80 ± 7.80 | 771.40 ± 34.64* | 547.90 ± 21.37*,# |
| Kidney (mg mm−1) | 40.52 ± 1.33 | 41.58 ± 1.34 | 55.22 ± 1.46* | 54.92 ± 1.60* |
| Perirenal fat (mg mm−1) | 11.32 ± 1.85 | 8.47 ± 1.63 | 183.70 ± 36.89* | 100.60 ± 27.25*,# |
| Left lung (mg mm−1) | 11.06 ± 0.20 | 10.65 ± 0.65 | 12.92 ± 0.69* | 11.02 ± 0.25# |
| Dry weight of left lung (mg mm−1) | 2.30 ± 0.03 | 2.16 ± 0.06 | 2.70 ± 0.08* | 2.42 ± 0.06# |
| 3 lobes of lung (mg mm−1) | 17.94 ± 0.41 | 16.40 ± 0.41 | 21.48 ± 1.64* | 17.23 ± 0.37# |
| Heart (mg mm−1) | 31.93 ± 0.66 | 28.74 ± 0.75* | 38.98 ± 0.95* | 35.40 ± 0.63*,# |
| Tibial length (mm) | 41.76 ± 0.35 | 42.54 ± 0.53 | 40.22 ± 0.42 | 39.89 ± 0.43 |
| Weight (g) | 407.70 ± 9.07 | 366.00 ± 7.67* | 523.80 ± 19.93* | 478.90 ± 8.73*,# |
Organs were weighted and indexed to the respective tibial length. Values are shown as mean ± SEM of n = 7–10 per group
Empa empagliflozin
* P < 0.05 vs control group and #P < 0.05 vs ZSF1 group