Table 2.
Population pharmacokinetic parameters of meropenem
| Parameter (units) | Median | Mean | 95% credibility limits | Standard deviation |
|---|---|---|---|---|
| CL (L/h) | 11.219 | 12.464 | 8.539–15.589 | 5.570 |
| V (L) | 10.143 | 12.500 | 8.385–17.194 | 6.929 |
| K12 (h−1) | 26.696 | 22.987 | 23.706–27.897 | 8.072 |
| K21 (h−1) | 7.601 | 11.721 | 3.853–21.014 | 9.730 |
| K13 (h−1) | 18.539 | 17.317 | 13.124–21.815 | 5.611 |
| K31 (h−1) | 25.614 | 24.451 | 23.575–28.602 | 5.892 |
| VELF (L) | 19.424 | 25.319 | 19.321–28.525 | 10.735 |
CL clearance; V volume of the central compartment; K12, K21, K13, and K31 first-order intercompartmental rate constants; VELF volume of the ELF compartment