Table 2.
Characteristics of the study participants according to the presence of microangiopathy in the EGF cohort (number or median (IQR)).
| Parameter | Value | |||
|---|---|---|---|---|
| All Participants (n = 100) | With Microangiopathy (n = 32) | Without Microangiopathy (n = 68) | p * | |
| Age, years | 29 (25–34.5) | 29 (25.5–34.5) | 29.5 (25–34.5) | 0.695 |
| Men, n (%) | 53 (53.0) | 19 (59.4) | 34 (50.0) | 0.381 ** |
| Smokers, n (%) | 18 (18.0) | 9 (28.1) | 9 (13.2) | 0.071 ** |
| T1DM duration, years | 12.5 (9–16) | 16 (14–18.5) | 11 (7–13.5) | <0.001 |
| Abnormal creatinine/albumin ratio, n (%) | 10 (10) | 9 (28) | 1 (1) | <0.001 *** |
| SBP, mmHg | 125 (120–130) | 130 (120–130) | 120 (120–130) | 0.449 |
| DBP, mmHg | 80 (70–83) | 80 (80–90) | 80 (70–80) | 0.073 |
| BMI, kg/m2 | 24.1 (22.1–26.8) | 24.6 (21.9–27.5) | 24.1 (22.2–26.4) | 0.851 |
| HbA1c, % | 7.4 (6.8–8.3) | 7.55 (6.95–8.1) | 7.35 (6.7–8.3) | 0.900 |
| hsCRP, mg/L | 1.08 (0.35–2.51) | 1.42 (0.66–2.34) | 0.97 (0.34–2.76) | 0.363 |
| ALT, U/L | 17 (13–21) | 18.5 (13–26) | 15.5 (13–21) | 0.213 |
| AST, U/L | 17 (15–20) | 18.5 (15–22) | 17 (14–20) | 0.273 |
| TC, mmol/L | 4.69 (4.09–5.37) | 4.84 (4.38–5.26) | 4.65 (4.00–5.54) | 0.739 |
| HDL, mmol/L | 1.68 (1.40–1.92) | 1.70 (1.37–1.98) | 1.68 (1.45–1.92) | 0.770 |
| LDL, mmol/L | 2.78 (2.23–3.38) | 2.68 (2.34–3.17) | 2.82 (2.15–3.52) | 0.787 |
| TG, mmol/L | 0.97 (0.70–1.27) | 1.07 (0.87–1.66) | 0.91 (0.66–1.20) | 0.058 |
| eGFR, mL·min−1·1.73 m−2 | 109 (96–118) | 102 (89–119) | 109 (99–117) | 0.233 |
| EGF, pg/mL | 36.5 (16–81.5) | 57.5 (28.5–100.5) | 28.5 (15–76) | 0.032 |
| Log10EGF | 1.56 (1.20–1.91) | 1.75 (1.45–2.00) | 1.45 (1.18–1.88) | 0.028 |
* p-value for comparison of groups in accordance with microangiopathy occurrence; ** χ2 test; *** Yates-corrected χ2 test; Mann–Whitney U test in every other case, where it is not marked with ** or ***. Abbreviations: ALT, alanine transaminase; AST, aspartate transaminase; BMI, body mass index; DBP, diastolic blood pressure; EGF, epidermal growth factor concentration; eGFR, estimated glomerular filtration rate; HbA1c, glycated hemoglobin; HDL, high-density lipoprotein; hsCRP, high-sensitivity C-reactive protein; IQR, interquartile range; LDL, low-density lipoprotein; Log10EGF, decadic logarithm of epidermal growth factor concentration; SBP, systolic blood pressure; T1DM, type 1 diabetes; TC, total cholesterol; TG, triglycerides; WHR, waist-to-hip ratio. A p-value less than 0.05 was considered statistically significant. The bolded p-values are those which are statistically significant.