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. 2020 Feb 18;12:31. doi: 10.1186/s13148-020-00827-3

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© The Author(s) 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Knockdown of CHD4 inhibits HCC cell migration and invasion. a, b Wound healing assay was performed to examine the effect of CHD4 knockdown on HCC cell migration. c, d Transwell invasion assay was performed to examine the effect of CHD4 knockdown on HCC cell invasion. e, f Expression levels of the EMT marker genes were detected in CHD4 knockdown cell lines and negative control cell lines by western blotting analysis and immunofluorescence staining. g Western blotting assay to examine the effects of CHD4 knockdown on histone modifications. h ChIP assay to examine the effects of CHD4 knockdown on histone modifications at the promoter of the CTNNB1 and Vimentin genes. *p < 0.05, **p < 0.01, ***p < 0.001, unpaired t test