Fig. 5.

miR-181b deletion in bone marrow-derived macrophages leads to increased TF expression and FXa generation upon inflammation. Bone marrow-derived macrophages (BMDM) were isolated from wt mice or miR-181−/− animals and cultured. The cells were either left untreated or stimulated with 1 µg/mL LPS for 4 h. Next, the miR-181b expression (a), asTF mRNA (b), flTF mRNA (c), FXa generation (d), and muTF protein (e) were measured. n = 3–6 animals per group, groups were compared by 2-way ANOVA test with global p-values for treatment with LPS and Sidak’s multiple comparison post hoc test