Table 1.
Patient characteristics
| Patient characteristics n = 46 |
Mean ± SD, median [IQR] or percentage | Correlation coefficient vs. miR-181b | p-value |
|---|---|---|---|
| Age (years) | 65.6 ± 9.3 | − 0.053 | 0.722 |
| Female gender (%) | 26.0 | 0.011 | 0.941 |
| BMI (kg/m2) | 30.6 [27.75–35.25] | 0.203 | 0.175 |
| Minimal fasting blood glucose (mg/dL) | 93.0 [75.75–128.3] | − 0.105 | 0.485 |
| Maximal fasting blood glucose (mg/dL) | 197.5 [140.5–238.8] | 0.146 | 0.332 |
| Average fasting blood glucose (mg/dL) | 139.1 [117.8–166.5] | − 0.012 | 0.934 |
| HbA1c (%) | 8.39 ± 1.61 | 0.2895 | 0.051 |
| HbA1c (mmol/mol) | 68.1 ± 17.7 | 0.2895 | 0.051 |
| CRP (mg/dL) | 0.40 [0.14–0.64] | − 0.051 | 0.733 |
| Leukocytes (N/nL) | 7.4 [6.37–9.12] | − 0.295 | 0.045* |
| Neutrophils (%) | 59.4 [52.03–66.65] | − 0.318 | 0.031* |
| Monocytes (%) | 6.83 ± 2.29 | 0.028 | 0.850 |
| d-Dimers (ng/mL) | 377.8 [247.4–523.5] | − 0.343 | 0.019* |
| Hemoglobin (g/dL) | 14.0 ± 1.2 | − 0.089 | 0.555 |
| Homocysteine (µmol/L) | 12.5 [10.95–17.08] | 0.071 | 0.637 |
| thrombocytes (N/nL) | 211.9 ± 51.7 | − 0.226 | 0.130 |
| Triglycerides (mg/dL) | 186 [110.3–271.0] | 0.222 | 0.136 |
| LDL cholesterol (mg/dL) | 113 [88–135] | 0.043 | 0.796 |
| miR-181b-5p | 0.169 [0.014–0.470] | 1 | |
| hypertension (%) | 100 | ||
| CAD (%) | 41.3 | − 0.177 | 0.236 |
| PAD (%) | 26.0 | − 0.096 | 0.521 |
| carotid stenosis (%) | 8.6 | − 0.133 | 0.375 |
| history of stroke (%) | 10.8 | − 0.249 | 0.094 |
| History of myocardial infarction (%) | 15.2 | − 0.006 | 0.964 |
| Medication | |||
| Insulin (%) | 69.5 | − 0.135 | 0.370 |
| Metformin (%) | 50.0 | 0.462 | < 0.001* |
| Sulfonylurea (%) | 17.3 | − 0.146 | 0.330 |
| Statin (%) | 50.0 | − 0.040 | 0.787 |
| Diuretics (%) | 60.8 | 0.164 | 0.274 |
| ACE inhibitor (%) | 47.8 | 0.114 | 0.447 |
| Angiotensin receptor blocker (%) | 28.2 | 0.194 | 0.194 |
| Aldosterone antagonist (%) | 8.6 | − 0.017 | 0.908 |
| Calcium antagonist (%) | 17.3 | − 0.177 | 0.239 |
| Nitrate vasodilators (%) | 13.0 | − 0.034 | 0.822 |
| Acetylsalicylic acid (%) | 58.7 | − 0.021 | 0.886 |
| Beta-blocker (%) | 50.0 | 0.194 | 0.194 |
N = 46, shown are either Pearson or Spearman correlation coefficients for normally and not normally distributed continuous variables, respectively. For binary variables, a point-biserial correlation was performed. Values presented are mean ± SD, medians [IQR] or percentages
ACE angiotensin-converting enzyme, BMI body mass index, CAD coronary artery disease, CRP c-reactive protein, HbA1c glycated hemoglobin, LDL low-density lipoprotein, MI myocardial infarction, PAD peripheral artery disease, TF tissue factor
*p<0.05