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. 2020 Jan 3;19(3):1797–1805. doi: 10.3892/etm.2020.8418

Figure 3.

Figure 3.

Overexpression of miR-103a-3p induces cisplatin resistance in NSCLC cells by activating ERK signaling. (A) miR-103a-3p positively regulates the phosphorylation of ERK in A549 cells. PC-9 cells were transfected with miR-103a-3p mimic or miR-103a-3p inhibitor. (B) ERK expression was significantly inhibited by ERK siRNA treatment in A549 cells. Cells were transfected with ERK siRNA. (C) Silencing of ERK abolished miR-103a-3p-induced cisplatin resistance in A549 cells. A549 cells were transfected with miR-103a-3p mimics and/or siRNA of ERK. After 24 h transfection, cells were treated with indicated concentration of cisplatin for 48 h. *P<0.05 and **P<0.01 with comparisons indicated by lines. miR, microRNA; NSCLC, non-small cell lung cancer; ERK, extracellular signal-regulated protein kinase; siRNA, small interfering RNA; NC, negative control; cDDP, cisplatin.