Fig. 3.

Prognostic germline variants that cause significant amino acid changes (CADD > 25) identified in analyses 4 through 6. a A description of the three analyses used to identify prognostic germline variants in this figure. b Analysis 4. Germline variants causing significant amino acid changes found to be predictive (FDR < 0.10) of patient outcome in each cancer. c Analysis 5. Germline variants causing significant amino acid changes found to be recurrently predictive (p < 0.05) of favorable (HR < 1) or poor (HR > 1) patient outcomes in 5 or more different cancers. d Analysis 6. Germline variants causing significant amino acid changes found to be predictive of patient outcome in patient groups defined in Fig. 1d