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. 2020 Feb 17;53:9. doi: 10.1186/s40659-020-00275-6

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — SYVN1 was a target mRNA of miR-34a-5p. a The expression of SYVN1 in OA tissues and normal tissues was detected by qRT-PCR. b The expression of SYVN1 in OA cells stimulated 10 ng/ml IL-1β and OA cells. c The predicted binding sites of SYVN1 to miR-34a-5p sequence using starBase 2.0. d The luciferase activity of 293T cells cotransfected with miR-34a-5p and luciferase reporters containing SYVN1-wt or SYVN1-mut was detected using luciferase reporter assay. e The expression of SYVN1 was detected in the samples bound to the Ago2 antibody or IgG by RIP assay. f, g The mRNA f and protein g expression of SYVN1 was detected in OA cells (IL-1β) transfected with NC, miR-34a-5p, anti-NC and anti-miR-34a-5p by qRT-PCR and western blot. *P < 0.05