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. 2020 Feb 17;21:12. doi: 10.1186/s40360-020-0391-x

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© The Author(s). 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Course of treatment 4 (combined HAMD cluster). Treatment effects of amantadine and placebo, respectively, measured by the difference in combined items of the HAMD-score, clustering for either melancholic (DENDOG) or retardation (DRETARD) features. For p-values and effect size indicators at different time points see Table 3 and Table 4