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. 2020 Feb 18;11:65. doi: 10.1186/s13287-020-01599-6

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© The Author(s) 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Diagram showing the development of fertilized and SCNT embryos; SCNT embryos had sperm small RNA in cattle. a Sperm enters oocytes, fertilizes, and initiates nucleus reprogramming and cytoskeleton remodeling. b Somatic cells were injected into enucleated oocytes, and SCNT embryos manifest abnormal nucleus reprogramming and cytoskeleton remodeling. c Sperm small RNAs were injected into SCNT embryos, and the treatment ameliorated abnormal nucleus reprogramming and cytoskeleton remodeling in SCNT embryos in cattle