Table 2.

The five most-enriched GO categories and KEGG pathways for the target genes of conserved and high sperm miRNAs (P < 0.05, FDR < 0.05)

ID	Term	Count	P value	FDR
Biological process
GO:0006351	Transcription, DNA-templated	254	2.65E−20	4.99E−17
GO:0045944	Positive regulation of transcription from RNA polymerase II promoter	155	7.38E−18	1.39E−14
GO:0006355	Regulation of transcription, DNA-templated	283	1.17E−17	2.21E−14
GO:0045893	Positive regulation of transcription, DNA-templated	95	1.89E−12	3.56E−09
GO:0000122	Negative regulation of transcription from RNA polymerase II promoter	111	4.19E−12	7.88E−09
Cellular component
GO:0005737	Cytoplasm	668	1.71E−22	2.56E−19
GO:0016020	Membrane	634	4.87E−10	7.31E−07
GO:0005634	Nucleus	588	1.92E−15	2.83E−12
GO:0005654	Nucleoplasm	208	4.08E−08	6.12E−05
GO:0005829	Cytosol	194	5.85E−08	8.78E−05
Molecular function
GO:0005515	Protein binding	473	8.29E−24	1.34E−20
GO:0046872	Metal ion binding	353	9.70E−11	1.57E−07
GO:0003677	DNA binding	227	5.16E−13	8.37E−10
GO:0000166	Nucleotide binding	198	2.71E−05	0.043909
GO:0016740	Transferase activity	161	4.83E−06	0.007827
KEGG pathway
mmu04151	PI3K-Akt signaling pathway	58	3.05E−08	3.97E-05
mmu04010	MAPK signaling pathway	46	4.87E−08	6.34E−05
mmu04810	Regulation of actin cytoskeleton	38	1.74E−06	0.002264
mmu04152	AMPK signaling pathway	27	3.35E−06	0.004361
mmu04550	Signaling pathways regulating pluripotency of stem cells	27	1.40E−05	0.018295