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. 2020 Feb 17;8:18. doi: 10.1186/s40478-020-0893-1

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© The Author(s). 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Ultrastructural analysis of muscles from Neb^Y2303H,Y935X mice confirmed nemaline bodies, tubular aggregates and pleomorphic mitochondria. a-c Electron microscopic images showing nemaline bodies (white arrowheads) and tubular aggregates (yellow arrowheads) from a 9-month-old male mouse. d-f Nemaline bodies originating from the Z disc identified in 8–12-month-old female mice. g-i Large intermyofibrillar aggregates of mitochondria were seen in all the muscles studied, with notable variation in mitochondrial size within the aggregates