Fig. 6.

Single myofibre measurements show reduced force, slower k_tr, and normal thin filament length. a In single-myofibre physiology measurements 6-month-old male Neb^Y2303H,Y935X mice had lower mean specific force compared with wild-type littermate controls. b Additionally, the mean k_tr (tension redevelopment) was slower in Neb^Y2303H,Y935X mice, however, c V₀ was unaffected. These results indicate a potential alteration of myosin cross-bridge kinetics underlying the force depression. Welch’s T-test, *p < 0.05. d The thin filament length was not altered in Neb^Y2303H,Y935X mice