Table 3.
Associations between CYP1A2, UGT1A4, and ABCB1 genotypes and autonomic nervous system activity
| CYP1A2 | ||||||
| rs2069514 | rs762551 | |||||
| G/G | G/A, A/A | P | C/C | C/A, A/A | P | |
| 56 | 35 | 21 | 70 | |||
| lnLF (ms2) | 4.40 ± 1.12 | 4.17 ± 1.11 | 0.337 | 4.84 ± 0.84 | 4.16 ± 1.15 | 0.013 |
| lnHF (ms2) | 3.86 ± 1.22 | 3.72 ± 1.05 | 0.597 | 4.15 ± 1.45 | 3.70 ± 1.03 | 0.119 |
| lnTP (ms2) | 4.98 ± 1.04 | 4.84 ± 0.92 | 0.511 | 5.37 ± 0.96 | 4.80 ± 0.97 | 0.020 |
| UGT1A4 | ||||||
| rs2011425 | ||||||
| T/T | G/T, G/G | P | ||||
| 73 | 18 | |||||
| lnLF (ms2) | 4.14 ± 1.07 | 5.06 ± 1.04 | 0.001 a | |||
| lnHF (ms2) | 3.59 ± 0.93 | 3.86 ± 1.20 | 0.378 | |||
| lnTP (ms2) | 4.82 ± 0.98 | 5.35 ± 0.95 | 0.042 | |||
| ABCB1 | ||||||
| rs1045642 | rs1128503 | |||||
| C/C | C/T, T/T | P | T/T | C/T, C/C | P | |
| 24 | 67 | 43 | 48 | |||
| lnLF (ms2) | 4.27 ± 1.19 | 4.34 ± 1.10 | 0.803 | 4.26 ± 1.07 | 4.37 ± 1.17 | 0.649 |
| lnHF (ms2) | 3.97 ± 1.12 | 3.75 ± 1.16 | 0.423 | 3.69 ± 1.19 | 3.91 ± 1.12 | 0.370 |
| lnTP (ms2) | 4.96 ± 1.03 | 4.92 ± 0.98 | 0.845 | 4,85 ± 1.01 | 5.00 ± 0.98 | 0.486 |
| ABCB1 | ||||||
| rs2032582 | rs2235048 | |||||
| G/G | G/A•T, A•T/A•T | P | T/T | C/C, C/T | P | |
| 16 | 75 | 24 | 67 | |||
| lnLF (ms2) | 4.11 ± 1.07 | 4.36 ± 1.13 | 0.419 | 4.27 ± 1.19 | 4.34 ± 1.10 | 0.803 |
| lnHF (ms2) | 3.80 ± 1.44 | 3.81 ± 1.09 | 0.977 | 3.97 ± 1.12 | 3.75 ± 1.16 | 0.423 |
| lnTP (ms2) | 4.83 ± 1.06 | 4.95 ± 0.98 | 0.665 | 4.96 ± 1.03 | 4.92 ± 0.98 | 0.845 |
Data are presented as mean ± standard deviation values
ln natural log-transformed, HF High frequency, LF Low frequency, TP Total power
a Significant difference (p < 0.007; Student’s t-test)