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. 2019 Dec 31;19(3):2127–2132. doi: 10.3892/etm.2019.8404

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Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — Roles of CCL22 in regulating the number and function associated makers of Tregs. (A and C) Stimulation of CD4⁺ T cells of RA patients with anti-CCL22 antibody (0.1, 0.2, 0.5, 1.0 and 2.0 µg/ml) caused apromoted effect on the number of Tregs, as well as a decrease of CCR4 while an increase in FOXP3 (C). (B and D) Stimulation of CD4⁺ T cells of HC with CCL22 protein (2, 10 and 50 ng/ml) caused inhibition of the number of Tregs (B), as well as increase in CCR4 while decreased FOXP3 (D). *P<0.05, **P<0.01 vs. control CD4⁺ T cells from RA; ^#P<0.05, ^##P<0.01 vs. control CD4⁺ T cells from HC. Tregs, regulatory T cells; CCR4, C-C chemokine receptor 4.