FIGURE 5.

Cell motility: Stage 0 (Steady state) -Cells maintain the connections to the ECM through the integrins; Stage 1 (Protrusion of the leading edge) -internal forces induce the F-actin polymerization and the water flow enters through the cell membrane; the actin polymerization induce the formation of protrusions; Stage 2 (Adhesion of leading edge) - the cortex under tension, accumulates new actin, through the movement of unpolymerized actin to the protrusion edge, and new adhesion molecules appear in the protrusion part. Stage 3 (Movement of the cell body) - there is the contraction of the cell in the same direction of the cell movement, and the water flow exits from the cell in the opposite direction, contributing to cell motility; Stage 4 (Deadhesion of the trailing edge) - Deadhesion on the cell back edge: the integrins in the back of the cell decreases, and new adhesion molecules appeared in the front of the cell in the same direction of cell movement based on Tao et al. (2017).