Figure 3.

Spike‐and‐wave discharges (SWDs) in bilateral Dcx‐knockdown (KD) rats are unrelated to the size of subcortical band heterotopia (SBH), although left‐right dominance exists. A, Number of SWDs in 24 hours plotted as a function of the size of SBH (depicted as cumulative area), and best‐fit linear regression line showing no relation between SBH size and the occurrence of SWDs. CI = confidence interval. B, Duration of SWDs (in minutes) in 24 hours plotted as a function of the size of SBH (depicted as cumulative area), and best‐fit linear regression line showing no relation between SBH size and the duration of SWDs. Dotted lines in A and B show 95% prediction bands of the regression lines. Open circles in A and B correspond to values for individual rats. C, Top, Stacked bar graphs showing the proportion of SWDs with a left‐ or right‐side onset, or with simultaneous onset in five bilateral Dcx‐KD rats implanted bilaterally in primary somatosensory (S1) cortex of the two brain hemispheres. Bottom, Stacked bar graphs showing the size of SBH in the left versus right hemisphere (expressed as percentage of the total SBH size) in the same rats. D, Serial frontal sections and dorsolateral view of the three‐dimensionally reconstructed brain of rat 337‐2, illustrating a larger rostrocaudal extent of the left SBH as compared to the right SBH (left and right SBH are in red; white matter is in blue). E, Examples of electroencephalographic traces simultaneously sampled from the left and right S1 cortex of rat 337‐2, showing SWDs with left‐side onset (left panel) and that were simultaneously detected (right panel)