Figure 5.

Spike‐and‐wave discharges (SWDs) in bilateral Dcx‐knockdown (KD) rats are modulated by ethosuximide (ETX). A, Bar graphs illustrating the occurrence and duration (in seconds) of SWDs for 18 hours after vehicle (top) and ETX (bottom) administration to a representative bilateral Dcx‐KD rat. SWD events (individual bars) are less frequent and of shorter duration (lower height of individual bars) after ETX. B, C, Line graphs showing the number of SWD events (B), and their duration (in minutes) in 24 hours (C) after vehicle and ETX administration, and after a 2‐day recovery period after ETX administration (post‐ETX). ns, not significant. D, Bar graphs illustrating the occurrence and duration (in seconds) of SWDs for 9 hours after vehicle (top) and carbamazepine (CBZ; bottom) administration to a representative bilateral Dcx‐KD rat. E, F, Line graphs showing the number of SWD events (E), and their duration (in minutes) in 12 hours (F) after vehicle and CBZ administration, and after a 2‐day recovery. Green dots in B, C, E, F correspond to values for individual rats