Table 1.
Differences between CD8+ and CD4+ Tregs
| CD8+ Treg | CD4+ Treg | |
|---|---|---|
| MHC | Class I, classical7 and non‐classical47 | Class II53 |
| Composition | Mostly memory3 | Naive and memory213 |
| Overall suppressive capacity | CD8> or =CD43, 32, 54 | |
| Suppression of memory and/or naive T cell responses | Memory and naive58 | Naive57 |
| Interferon gamma mediated suppression | Repeatedly described3, 4, 65, 73, 74, 75, 76, 77 | Rarely described70, 78 |
| IL‐2 induced proliferation | CD8> or =CD432, 103, 104, 105, 106, 107 | |
| IL‐15 induced proliferation | CD8> or =CD43, 54, 61, 111, 112, 113, 114 | |
| Preferred polyclonal stimulation | mAbs3 | Beads146, 147, 148, 149 |