Testing strategy (age range for testing; colonoscopic surveillance interval)	Cases of cancer	Cancer deaths	Colonoscopies	Cancer deaths averted	Colonoscopies to avert one death
Stage 1 analysis
1. No testing	1566	630	—	—	—
7. MSI + MLH1 methylation (no age limit; 1 year)	1248	446	30 597	184	166
6. MSI + BRAF V600E (no age limit; 1 year)	1246	445	30 697	185	166
5. MSI (no age limit; 1 year)	1243	442	30 865	187	165
4. IHC + MLH1 methylation (no age limit; 1 year)	1243	442	30 952	188	165
3. IHC + BRAF V600E (no age limit; 1 year)	1242	441	30 995	189	164
2. IHC (no age limit; 1 year)	1241	440	31 084	189	164
8. Universal gene panel testing (no age limit; 1 year)	1239	438	31 257	192	163
Stage 2 analysis
1. No testing	1566	630	—	—	—
3.3. IHC + BRAF V600E (< 50 years; 2 years)	1500	583	4778	46	103
3.2. IHC + BRAF V600E (< 50 years; 1 year)	1491	582	9457	48	198
8.3. Universal gene panel testing (< 50 years; 2 years)	1500	583	4837	47	103
8.2. Universal gene panel testing (< 50 years; 1 year)	1491	581	9571	49	196
3.5. IHC + BRAF V600E (< 60 years; 2 years)	1398	518	10 642	112	95
8.5. Universal gene panel testing (< 60 years; 2 years)	1396	516	10 756	114	94
3.4. IHC + BRAF V600E (< 60 years; 1 year)	1375	513	20 976	117	180
8.4. Universal gene panel testing (< 60 years; 1 year)	1374	511	21 197	119	179
3.7. IHC + BRAF V600E (< 70 years; 2 years)	1319	471	14 251	159	90
8.7. Universal gene panel testing (< 70 years; 2 years)	1317	468	14 383	161	89
3.6. IHC + BRAF V600E (< 70 years; 1 year)	1287	464	27 970	165	169
8.6. Universal gene panel testing (< 70 years; 1 year)	1284	462	28 226	168	168
3.1. IHC + BRAF V600E (no age limit; 2 years)	1279	449	15 860	181	88
8.1. Universal gene panel testing (no age limit; 2 years)	1275	446	15 999	184	87
3. IHC + BRAF V600E (no age limit; 1 year)	1242	441	30 995	189	164
8. Universal gene panel testing (no age limit; 1 year)	1239	438	31 257	192	163

IHC = immunohistochemistry; MSI = microsatellite instability.