Figure 6.

Schematic diagram of proposed signaling by a putative membrane glucocorticoid receptor (mGR). We propose two signaling pathways mediated by glucocorticoids, the canonical cytosolic GRα receptor mediating direct genomic effects via GRE and a second, non‐genomic activation of G_αs and cAMP signaling (illustrated here as signaling via CREB for simplicity, but other transcription factors are likely involved). The latter can have both rapid effects and effects that contribute to the genomic actions of glucocorticoids