Naspitz 1992.

Methods	Randomised double blind clinical controlled trial
Participants	61children (33 males 28 females), ages 8‐24 months Patients with acute wheezing seen in the emergency department. excl. febrile, cyanosis. Wheeze alone on auscultaion
Interventions	Fenoterol (0.5% aqueous soln. 1 drop/ 3kg) + 4 drops of 0.9% saline vs fenoterol (0.5% aqueous soln. 1 drop/ 3kg) + 4 drops ipratropium bromide 0.025% soln. Single treatment using ultrasonic nebuliser (CEL‐SP).
Outcomes	Clinical score at 15, 30 & 45 minutes (Ben‐Zvi). Requirement for further treatment at 45 mins.
Notes	No placebo arm, none with crepitations on auscultat.
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Low risk	A ‐ Adequate