Wang 1992.

Methods	Ranndomised placebo controlled double blind trial.
Participants	62 patients, aged 2 months to 24 months. Hospitalised for first time with acute wheeze.
Interventions	Nebulised therapy 4 hourly. 1) Salbutamol (0.15mg/kg/dose) (sal)+ placebo (0.9% saline) 2) Placebo + ipratropium bromide (125mcgs if<6/12 ‐ 250mcg if>6/12) (IpBr) 3) Sal + IpBr 4) placebo = placebo
Outcomes	Change in oxygen saturation from baseline at discharge or day 3. Change in clinical score from baseline at discharge or day 3. Duration of hospitalisation.
Notes	Over 90% were treated with inhaled salbutamol prior to admission with an 'inadequate' response. Responders were discharged from the emergency room and not eligible for the study.
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Low risk	A ‐ Adequate