Summary of findings for the main comparison. Bupropion for smoking cessation.
| Bupropion for smoking cessation | ||||||
| Patient or population: people who smoke Intervention: bupropion | ||||||
| Outcomes | Illustrative comparative risks* (95% CI) | Relative effect (95% CI) | No of Participants (studies) | Quality of the evidence (GRADE) | Comments | |
| Assumed risk | Corresponding risk | |||||
| Control | Bupropion | |||||
| Bupropion versus placebo/control. Abstinence Follow‐up: 6+ months | 115 per 10001 | 187 per 1000 (172 to 203) | RR 1.62 (1.49 to 1.76) | 13728 (44 studies) | ⊕⊕⊕⊕ high2,3 | |
| Bupropion and NRT versus NRT alone. Abstinence Follow‐up: 6+ months | 186 per 10001 | 221 per 1000 (175 to 281) | RR 1.19 (0.94 to 1.51) | 3487 (12 studies) | ⊕⊕⊝⊝ low3,4,5 | |
| Bupropion versus NRT. Abstinence Follow‐up: 6+ months | 254 per 10001 | 244 per 1000 (216 to 277) | RR 0.96 (0.85 to 1.09) | 4086 (8 studies) | ⊕⊕⊕⊝ moderate4 | |
| *The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: Confidence interval; RR: Risk ratio; | ||||||
| GRADE Working Group grades of evidence High quality: Further research is very unlikely to change our confidence in the estimate of effect. Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low quality: We are very uncertain about the estimate. | ||||||
1 Control risk calculated as mean across included studies 2 Sensitivity analyses including only those studies judged to be at low risk of bias did not impact the pooled results 3 Funnel plot did not show evidence of asymmetry 4 All but one study at unclear or high risk for selection bias 5 Inconsistency across pooled results (I squared = 52%)