Uyar 2007.

Methods	BUPROPION Randomized controlled trial Setting: cessation clinic, Turkey Recruitment: cessation clinic patients
Participants	131 smokers; 81% M, av. age 36
Interventions	1. Bupropion 300mg for 7 weeks 2. Nicotine patch 21mg for 6 weeks incl tapering 3. Advice and follow up only All arms: Brief counselling on consequences of smoking with follow up for 24 weeks‐ more than low intensity
Outcomes	Abstinence at 24w (not defined) Validation: CO < 10 ppm
Notes	First included based on abstract. Contributes to bupropion vs control and bupropion vs nicotine patch Funding not reported
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	'Randomly allocated', method not described, unclear why fewer in control condition.
Allocation concealment (selection bias)	Unclear risk	Allocation concealment not described.
Blinding (performance bias and detection bias) All outcomes	High risk	Open‐label
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	No mention of any losses to follow‐up.