Selby 2003.

Methods	BUPROPION Randomized controlled trial Setting: 15 clinical centres, Canada Recruitment: community volunteers
Participants	284 smokers previously exposed to bupropion for at least 2w, not quit for more than 24 hours in previous month
Interventions	1. Bupropion 300mg for 12w 2. Placebo Behavioural support not described
Outcomes	Abstinence at 12m (PP) Validation: CO <= 10 ppm at treatment visits
Notes	Based on abstract Funding not reported
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Randomization method not described.
Allocation concealment (selection bias)	Unclear risk	No details given.
Blinding (performance bias and detection bias) All outcomes	Unclear risk	No details given.
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	No details given, unclear how participants lost to follow‐up treated in outcome data. 70% intervention group and 50% control group completed study.