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. 2020 Jan 13;98(2):138–151. doi: 10.1111/imcb.12309

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© 2019 The Authors. Immunology & Cell Biology published by John Wiley & Sons Australia, Ltd on behalf of Australian and New Zealand Society for Immunology, Inc.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Macrophage (Mϕ) suppressed natural killer (NK) degranulation over time in MNC trioculture. NK, Mϕ, and myco⁻ and myco⁺ chronic myeloid leukemia (CML) were incubated in mono, duo and triocultures according to the experimental strategies outlined in (a) (24 h) and (b) (4 h). CFSE⁻CD14⁻CD56⁺ NK cells were then gated and CD107a⁺ NK cells were determined. Results shown are mean ± s.e.m. of three independent experiments (donors). See Supplementary figure 11 for individual replicate experiments. Statistical significance was determined using repeated measures one‐way ANOVA followed by Tukey's test. **P < 0.01. CFSE, carboxyfluorescein succinimidyl ester; MN, Mϕ + NK; MNC, Mϕ + NK + CML; N, NK alone; NC, NK + CML; ns, nonsignificant.