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. 2020 Feb 14;13:399–410. doi: 10.2147/JPR.S240011

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Role of the endocannabinoid system in the control of pain at peripheral, spinal, and supraspinal levels. Cannabinoid receptor activity inhibits the ascending nociceptive transmission, activates the inhibitory descending pathway, and modifies the emotional component of pain. CB₁R, Cannabinoid type 1 receptor; CB₂R, Cannabinoid type 1 receptor. Reproduced with permission from Maldonado R, Baños JE, Cabañero D. The endocannabinoid system and neuropathic pain. Pain. 2016;157(Suppl 1):S23–S32. Available from: https://insights.ovid.com/article/00006396-201602001-00005.⁴⁰