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. Author manuscript; available in PMC: 2021 Feb 1.
Published in final edited form as: Hypertension. 2019 Dec 23;75(2):569–579. doi: 10.1161/HYPERTENSIONAHA.119.14056

Figure 3. Reduced feto-placental expression of Rgs2 induces changes in GD12.5 placental gene expression consistent with PreE.

Figure 3.

(A) Heat map illustrating relative expression of differentially upregulated (479) and downregulated (247) genes identified by DeSeq2 (FDR < 0.1) (Littermate n=6, Rgs2-KO n=6 placentas, each from an independent pregnancy). (B) Venn diagrams demonstrating comparisons of the up- and downregulated genes in Rgs2-heterozygous placentas to genes similarly changed in human placentas from pregnancies affected by PreE.20, 36–38 Numbers indicate the total number of genes significantly changed in the individual datasets, or shared between datasets.