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. Author manuscript; available in PMC: 2020 Dec 1.
Published in final edited form as: Small. 2019 Nov 7;15(52):e1904378. doi: 10.1002/smll.201904378

Figure 2.

Figure 2.

Formulation of Fer capped ICB-UPMSNP. A) ζ-potential of particles is measured by dynamic light scattering. The carboxyl residue decorating Fer and the amine residue on the UPMSNPs showed −24.4 mV and +28.5 mV, respectively. ICB-UPMSNP (+10.2 mV) can be capped with Fer. Fer capped ICB-UPMSNP had −12.6 mV. B) TEM images of ICB-UPMSNP and Fer-ICB-UPMSNP after 7 d. C) Fer capping after ICB loading to UPMSNPs resulted in the sustained release of antibodies compared to uncapped ICB-UPMSNPs. Without Fer capping of UPMSNP completely releases ICB within 72 h. D) T2 weighted MRI and T2 signal changes with increased concentrations of Fer and Fer-ICB-UPMSNP. Samples were dispersed into the 1% agarose to obtain the phantom T2W images with 7T MRI.