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Phasing and linkage disequilibrium in CYP2B6. (a) High linkage disequilibrium is shown by the frequencies of the CYP2B6*4 and *9 variants in all automatically phased haplotypes (N = 2,948 alleles), when combined the haplotype is *6. χ2, P < 0.0001. (b) Possible configurations for the CYP2B6 variants, leading to different phenotypes. Numbers are based on all individuals who carried both variants and could be phased automatically (N = 415).
