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. Author manuscript; available in PMC: 2020 Mar 1.
Published in final edited form as: Neurobiol Dis. 2020 Jan 10;136:104740. doi: 10.1016/j.nbd.2020.104740

Figure 2. FXTAS Neuropathology.

Figure 2.

Postmortem neuropathological analysis from human FXTAS cases show a characteristic neurodegenerative phenotype which includes ventricular enlargement (A); focal white matter lesions (B,C); ubiquitinated intranuclear inclusion bodies (D,E – ubiquitin IHC with hematoxylin nuclear counterstain); patches of astrogliosis (F,G - GFAP IHC); and excessive iron accumulation (H,I – ferric iron stained using Perl’s method, Eosin counterstain).