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. 2012 Oct 17;2012(10):CD001321. doi: 10.1002/14651858.CD001321.pub5

Linsenmeyer 2004.

Methods
  • Design: Cross‐over RCT

  • Power calculation: NS

  • ITT analysis: no

Participants Inclusion criteria
  • Setting: patients presenting to outpatient urology rehabilitation clinic; single centre

  • Country: USA

  • Patients with neurogenic bladders secondary to spinal cord injury

  • Number: 37 randomised; 21 analysed


Exclusion criteria: NS
Interventions Treatment group
  • Cranberry tablets: 400 mg standardised tablets


Control group
  • Placebo


Duration of treatment: 9 weeks (4 weeks on each, plus one week wash out)
Outcomes
  • Urinary bacterial counts and WBC counts and the combination of bacterial and WBC counts

Notes Exclusions post randomisation: none
Method of obtaining urine sample
  • CSU or MSU


Definition of bacteriuria
  • MSU: ≥ 10,000/mL

  • CSU: > 100 cfu/mL

Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk NS
Allocation concealment (selection bias) Unclear risk NS
Blinding of participants and personnel (performance bias) 
 All outcomes Low risk States participants and researchers blinded
Blinding of outcome assessment (detection bias) 
 All outcomes Low risk States researchers are blinded, assume outcomes assessors included
Incomplete outcome data (attrition bias) 
 All outcomes Low risk All patients accounted for in results and analysis; losses to follow‐up/withdrawals: 16
Selective reporting (reporting bias) Low risk Primary outcome is appropriate
Other bias Unclear risk Some methods are vague, not a well reported study
Source of funding: Eastern Paralyzed Veterans Association