UKTTG 1994.

Methods	Multi‐centre, parallel‐group study
Participants	187 patients aged 18‐75
Interventions	Tizanidine (up to 36mg) v. placebo
Outcomes	Primary outcome measure: Ashworth scale. Secondary measures: muscle power (MRC grade), EDSS score, reflexes, clonus, spasm score, 8m walking time, scales of intermediate motor skills and upper limb functions, ADL (Incapacity Status Scale), subjective assessments of overall effect on function, efficacy and tolerability
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Unclear risk	B ‐ Unclear