Study	Reason for exclusion
Abel 1994	Not RCT of sufficient duration
Anonymous 1973	Not RCT of sufficient duration
Anonymous 1974	Not RCT of sufficient duration
Azouvi 1996	Not RCT of sufficient duration
Barat 1974	Not a randomised controlled trial
Barbeau 1982	Not RCT of sufficient duration
Basmajian 1973	Unable to extract data for non‐MS patients
Baykuschev 1968	Not RCT of sufficient duration
Becker 1995	Not RCT of sufficient duration
Behan 1982	Not RCT of sufficient duration
Bergamini 1966	Not a randomised controlled trial
Bianchi 1999	Not RCT
Birkmayer 1967	Not RCT
Bittencourt 1988	Not RCT of sufficient duration
Broggi 1993	Not RCT of sufficient duration
Broseta 1989	Not RCT of sufficent duration
Burke 1971	Not RCT of sufficient duration
Cartlidge 1974	Unable to separate data for non‐MS patients
Castaigne 1973	Not a randomised controlled trial
Cendrowski(1) 1977	Not RCT of sufficient duration
Cendrowski(2) 1977	Not RCT of sufficient duration
Chantraine 1980	Not RCT of sufficient duration
Chipman 1974	Not RCT of sufficient duration
Chyatte 1971	Not RCT of sufficient duration
Coffey 1993	Not RCT of sufficient duration
Cohan 1980	Not RCT of sufficient duration
Corston 1981	Unable to separate non‐MS patients
Cumming 1972	Not RCT of sufficient duration
Cutter 2000	Not RCT of sufficient duration
Dressnandt 1996	Not RCT of sufficient duration
Duncan 1976	Unable to separate data for non‐MS patients
Dunevsky 1998	Not an RCT
Emre 1994	Not RCT of sufficient duration
Finnimore 1995	Not relevant to this review
Fra 1971	Not a randomised controlled trial
Gambi 1983	Unable to extract data for non‐MS patients
Gerstenbrand 1979	Not an RCT
Gibbins 1982	No evidence of blinding in published report
Glass 1974	Not RCT of sufficient duration
Gobel 1999	Not RCT of sufficient duration
Gonsette 1978	Not RCT of sufficient duration
Hassan 1980	Not RCT of sufficient duration.
Heazlewood 1983	Not RCT of sufficient duration
Hedley 1975	Not RCT of sufficient duration.
Herman 1992	Unable to separate data for non‐MS patients.
Hoogstraten 1988	Single‐blind study only
Hudgson 1971	Unable to separate data for non‐MS patients
Huffman 1973	Not RCT of sufficient duration
Hugenholtz 1992	Unable to separate data for non‐MS patients
Jabbari 1995	Not RCT of sufficient duration
Jabbari 1996	Not RCT of sufficient duration
Jarrett 2002	Not RCT
Jerusalem 1968	Not RCT
Jones 1976	Not RCT of sufficient duration
Joynt 1976	Not RCT of sufficient duration
Keenan 1977	Unable to separate data for non‐MS patients
Kerty 1997	Not RCT of sufficient duration
Ketelaer 1973	Not a randomised controlled trial
Khan 1995	Not RCT of sufficient duration
Knutsson 1982	Not RCT of sufficient duration
Kravitz 1992	Not RCT of sufficient duration.
Ladd(1) 1974	Not RCT of sufficient duration
Ladd(2) 1974	Not RCT of sufficient duration.
Latash 1989	Not RCT of sufficient duration
Lazorthes 1990	Not RCt of sufficient duration
Lee 1993	Unable to separate non‐MS patients
Lee 1994	Not relevant to this review
Leveghi 1998	Not RCT
Levine 1968	Not RCT of sufficient duration
Levine 1969	Not RCT
Levine(1) 1977	Unable to separate data for non‐MS patients
Levine(2) 1977	Not RCT of sufficient duration
Link 1999	Not RCT
Lossius 1985	Not RCT of sufficient duration
Loubser 1991	Not MS patients
Mai 1979	Not RCT of sufficient duration
Mayer 1973	Not RCT of sufficient duration
Medici 1985	Unable to separate non‐MS patients
Meinck 1989	Not RCT of sufficient duration
Meyler 1981	Not RCT of sufficient duration
Mondrup 1983	Not RCT of sufficient duration
Mondrup 1984	Drug not used therapeutically for toxicity
Monster 1973	Unable to separate data for non‐MS patients
Monster 1974	No details of patients' diagnoses. No validated outcome measure used. Unable to extract details of first crossover period
Morita 2001	Not RCT
Mueller 1997	Not RCT of sufficient duration
Muller 1987	Not RCT of sufficient duration
Mutani 1971	Not a randomised controlled trial
Nance 1995	Not RCT of sufficient duration
Nance 1997	Not relevant to this review
Neretin 1978	Not RCT of sufficient duration
Newman 1982	Unable to separate data for non‐MS patients
Nielsen(1) 2000	Not RCT
Nielsen(2) 2000	Not RCT
Ochs 1989	Not RCT of sufficient duration
Ordia 1996	Not RCT of sufficient duration
Orsnes(1) 2000	Not RCT
Orsnes(2) 2000	Not RCT
Pagano 1988	Unable to separate data for non‐MS patients
Parke 1989	Not RCT of sufficient duration
Patterson 1994	Not RCT of sufficient duration
Pederson 1970	Not RCT of sufficient duration
Pederson 1981	Not RCT of sufficient duration.
Penders 1976	Not RCT of sufficient duration.
Penn 1985	Not RCT of sufficient duration.
Penn 1989	Not RCT of sufficient duration.
Penn 1992	Not RCT of sufficient duration.
Perkin 1976	Drug not used therapeutically for toxicity
Petro 1980	Not RCT of sufficient duration.
Petro 1981	Not RCT of sufficient duration.
Polman 1994	Not RCT of sufficient duration
Porsasz 1981	Not a randomised controlled trial
Reisner 1978	Not a randomised controlled trial
Ringwald 1977	Not RCT
Rodgers 1999	Not RCT
Rossier 2000	Not RCT
Roussan 1982	Unable to separate data for non‐MS patients
Rudick 1987	Drug not used therapeutically for toxicity
Saltuari 1992	Not RCT of sufficient duration
Smith 1991	Not RCT of sufficient duration
Smith 1992	Not RCT of sufficient duration
Toste 1999	Not RCT
Ungerleider 1987	Not RCT of sufficient duration
van Ouwenaller 1985	Not MS patients
Verrier 1977	Not RCT of sufficient duration
Vogt 2000	Not RCT
Weiser 1978	Unable to separate data for non‐MS patients
Wickstrom 1987	Unable to obtain further details of study
Wilson 1966	Unable to separate data for non‐MS patients