Fraser 1982.

Methods	Randomization method not stated Blinding: double Lost to follow‐up: 0/60 at 2 yrs 4/60 at 10 yrs
Participants	60 pts; 39 m, 21 f; age 19‐69 yrs Adelaide, Australia Failed conservative treatment (unknown duration) within preceding 6 mths Myelogram demonstrating posterolateral herniated disc at single level
Interventions	Exp: chymopapain (8 mg in 2 mls) Ctl: saline (2 mls)
Outcomes	Surgeon rating Patient rating 2nd procedure required ‐ at 2, 10 yrs
Notes	6 mths, 2 yrs and 10 yrs follow‐up reported in separate publications
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Low risk	A ‐ Adequate