| Methods |
Randomised controlled trial. Randomisation was based on date of admission
Analysis not ITT |
| Participants |
45 patients with blunt trauma who required colloid infusion. Patients were excluded if they were less than 12 years old, did not require admission to the ITU, died within 24 hours, were pregnant or in renal failure
8 gelatin and 6 HES patients excluded after randomisation |
| Interventions |
1) HES (200/0.45 Pentaspan) (n = 24)
2) Gelatin (Gelofusine) (n = 21)
After 24 hours, colloid administration was at the discretion of the clinician |
| Outcomes |
Death
Glasgow coma score
Volumes of blood and platelets infused
Haematological parameters |
| Notes |
Data were collected until the patient left the ITU or for a maximum of 5 days. Main outcome of interest was capillary leak |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment (selection bias) |
High risk |
Inadequate. Randomisation was based on date of admission (on even dates patients received HES) |
