| Methods |
Randomised controlled trial |
| Participants |
28 patients with hypovolaemia, mechanically ventilated for concurrent acute respiratory failure. Patients fulfilled the following inclusion criteria: age >16 years, body weight between 50 kg and 85 kg, MAP < 80 mmHg (or 30 mmHg less than previously recorded); PAOP < 10 mmHg with oliguria (i.e. urine output < 15 mL/hour) |
| Interventions |
1) Rapid infusion of 500 mL MFG (n = 15)
2) Rapid infusion of 500 mL hetastarch (n = 13) |
| Outcomes |
Death
Haemodynamic variables
Oxygen variables |
| Notes |
Follow‐up 30 minutes for haemodynamic variables and until discharge for deaths. Information on allocation concealment was obtained on contact with the study author |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment (selection bias) |
High risk |
Inadequate. Allocation by alternation |
