| Methods |
Randomised controlled trial. No blinding |
| Participants |
48 patients undergoing major elective hip surgery with an expected blood loss of > 1000 mL. Exclusion criteria were Hb concentration 11 g/dL or less; heart failure and coronary artery disease; MI within the past 6 months; hypertension (> 180 mmHg systolic); impaired renal function; pregnancy; known hypersensitivity to HES or gelatin; patient taking drugs that may specifically affect blood viscosity, diuresis, or clotting |
| Interventions |
1) 3% MFG (n = 22)
2) 6% HES (n = 19)
Both groups also given RL. Fluids administered according to haemodynamic and clinical parameters |
| Outcomes |
Death (information on death was obtained by contact with the study author)
Haemodynamic variables
Packed cell volume, Hb, clotting times
Incidence of allergic reactions |
| Notes |
7 patients were lost to follow‐up but only 5 were accounted for. Information on method of allocation concealment was obtained by contact with the author |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment (selection bias) |
Low risk |
Adequate. Allocation was by a list of random numbers read by someone not entering patients into the trial (closed list) |
