Boldt 1996a.

Methods	Randomised controlled trial. Outcome assessors blinded to treatment
Participants	30 trauma patients and 30 patients with from sepsis secondary to major general surgery. Exclusions were patients with renal impairment, liver insufficiency, disseminated intravascular coagulation, or septic shock
Interventions	1) 10% HES (n = 30) 2) 20% HA solution (n = 30) All patients also received RL Volume therapy was given to maintain PCWP between 12 mmHg and 18 mmHg
Outcomes	Death Haemodynamic variables
Notes	Follow‐up at 5 days and at discharge from ICU
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment (selection bias)	Low risk	Adequate. Allocation by sequentially numbered sealed opaque envelopes